When I walked into Dr. Kelly Baek’s office the spring of 2016, I was shaking. It felt like a huge chance in front of me to start a family that I wanted so badly, yet also my last chance at that vision. I had already tried naturally for so long, done six rounds of clomid, almost a dozen trigger shots. What else could be done? I knew that IUI and IVF were options for some, but I wasn’t so sure that conceiving my own babies was in the cards for me so it felt like the beginning of a roller coaster, when there’s that pit in your stomach, where you know there’s a big ride ahead, that’s going to bring a thrilling series of lots of ups and downs. If you haven’t read the beginning of my IVF journey, you can check it out here where I pour out my heart and soul. And if you’ve been following me for some time, you know that I now have not one, two but three beautiful babies as my happy ending. It was a journey to come here, and it was Dr. Baek who took every essential step for me to meet this family of my dreams.

Please say hello to Dr. Kelly Baek, the woman who made it all happen, and who so gracefully offered her time to me over the past weeks to chat through the facts, your questions, the emotions that come with infertility. She even gave us a peak into her personal life as a fertiltiy specialist (who works every single day of the week) which I’ll share in part two of this interview!

What research is being done to explainunexplained infertility?”
What I have learned and have discussed with my colleagues nationwide is that “unexplained infertility” is not truly “unexplained”. Most patients “unexplained” infertility are patients who are either sub-fertile or who have etiologies or causes that have not been uncovered yet.  For years, the uterine lining was a mystery.  We could do our best to develop genetically normal embryos but we would transfer them into the uterus and hope for success.  When transfers failed, we would perform hysteroscopies, add additional medications and supplements and sometimes look for immunologic causes for implantation failure.  Now with the different endometrial biopsies including the endometrial function test at Yale and the endometrial receptivity assay, we are uncovering more answers for why transfers may not have been successful.  Finally, I personally have found that endometriosis which affects 1 in 10 women is underdiagnosed and oftentimes the reason couples with completely “normal” fertility work-ups are not successful.

Many women are misdiagnosed prior to visiting your officewhat is the most common scenario you see?

Oftentimes, I find that women undergo fertility treatments including IUI and ivf cycles before undergoing a basic fertility assessment: hysterosalpingogram, hormonal assessment and semen analysis.

I also see patients who believe they had an evaluation. Some believe they had a hysterosalpingogram, HSG, which is the gold standard to assess the uterine cavity and fallopian tubes which is performed with a radiologist only to learn they had a saline hysterosonogram which is a different test.  Further, for women who have had a hysterosalpingogram, it is critical for fertility specialists to view the images themselves and not rely on reports as there are findings that are important for fertility specialists that differ from radiologists.  Is the uterus midline? deviated to the right or left? Is there a straight AP (anterior posterior) view or is the view of the uterus from the top or bottom.  Unless the view is straight on, it is challenging to rule out congenital uterine anomalies that can prevent implantation and increase the risk of miscarriage such as a uterine septum.  I also look to see if the tubes fill and spill with dye but I also assess the caliber of the tubes.  Normal tubes are thin and threadlike. Dilated fallopian tubes called hydrosalpinges are associated with lower pregnancy and increased miscarriage rates as toxic fluid within the dilated tubes can reflux into the uterus.

Many patients provide IUI sample reports when asked for semen analysis reports.  IUI samples only have concentration and motility on the reports.  Morphology is not assessed with an IUI since slides need to be made to count the number of normal shaped sperm.  Once sperm are smeared on slides to be viewed under a microscope, the sperm are not viable. Therefore, IUI samples where semen is washed and prepped for insemination are not assessed for morphology.  A complete semen analysis includes concentration, motility and morphology.

For every patient, I insure a basic fertility evaluation (semen analysis, hysterosalpingogram, hormonal assessment) and tests dictated by their specific medical history before I proceed with any fertility treatment.

You diagnosed me with Adenomyosissomething my former gynecologist completely missed 6 months priorDo you see a misdiagnosis happening a lot with patients?

Adenomyosis is endometriosis that is inside the uterus.  Endometriosis affects 1 in 10 women.  It is missed in many patients.  Many women are diagnosed as having GI disorders, menstrual irregularities, etc instead of being diagnosed with endometriosis.  There is a misconception that if you don’t have severe pain with your periods you can’t have endometriosis.  I suspect endometriosis in women :

*who have a lower ovarian reserve than expected for their age
*who have a uterus deviated to the right or left
*who have one ovary with much less ovarian activity than the opposite ovary
*who have an endometrioma or adenomyosis findings on ultrasound

In addition to ovarian reserve testing and ultrasound, a pelvic exam oftentimes will reveal thickened uterosacral ligaments.  Blood, ultrasound and pelvic exam findings together help make the diagnosis.  Adenomyosis can be detected on ultrasound but specialists need to know what to look for.  I perform hundreds of ultrasounds weekly and therefore have a keen eye for ultrasound findings.
Identifying endometriosis in women who have been misdiagnosed for years has been life altering for many patients.  There are studies that women with endometriosis are diagnosed a decade after their initial presentation.

Whats the most common scenario you see?
For women with undiagnosed Adenomyosis – I see women who have had repeated failed iui, ivf and FET cycles even with genetically normal embryos and recurrent miscarriages.

I remember you advising me to cut out sugar and eat lots and lots of high fat and protein to increase egg quality. Would you advise this to all women trying to conceive? Whats the best fertility diet in general?
I don’t believe there is one perfect fertility diet.  I believe everything in moderation is ideal.  No carb, keto or atkins diets which can suppress ovarian activity.  Keto diet is to try to get your body into a state of starvation aka ketosis.  Therefore it is not surprising that this diet can suppress ovarian activity and ovulation. I advise against high sugar consumption.  The membrane of the egg is made up of lipid or fat cells so I advise patients to consume good fats.  When women consume seafood multiple times a week, I check mercury levels.  Even when women consume organic wild caught fish, they can have high mercury levels.  I address and change their diet to cut down their seafood intake if mercury levels are elevated.  I also recommend small frequent meals to avoid glucose highs and lows.

How long should you try to conceive naturally before seeking a specialist?

My answer DIFFERS than the textbook answer which is for women under 35 yo to consult a specialist after trying to conceive after 1 year and for women over 35yo after 6 months.
If you answer yes to any of the following questions, you should see a fertility specialist before you start trying to conceive.  Simply consulting a specialist does not mean that you will need fertility treatments, but it will help you avoid trying to conceive only to learn after 6 months or 1 year that you were trying to conceive in vain.
1. Is there a family history of premature ovarian failure? Did your mother enter menopause early ? in her 40’s?
2. Are your menstrual cycles irregular? Just because you get a period every month does not guarantee that you ovulate properly.
3. Do you have thyroid or any autoimmune issues?
4. Have you ever had a sexually transmitted disease?
5. Have you had PAP smears requiring excision of a part of your cervix called a cone biopsy or leep procedure or “freezing” (cryotherapy) of your cervix?
6. Do you have a history of a eating disorder or history of smoking/vaping/drugs or using pot?
7. Are you a single woman or a single man? Are you in a same sex relationship?
8. Did you have childhood cancer?
9. IF you have a male partner – does he smoke pot, cigarettes or vape? Does your male partner use propecia? Does he have a history of undescended testes or any testicular or inguinal hernia surgeries? Does he have any autoimmune, chronic or cancer history? Does he have difficulty maintaining an erection or ejaculating? Does he have a history of any sexually transmitted diseases?
Best supplements for age 37+to aid fertility?
*A prenatal vitamin that has methylated folate (the form of folic acid that absorbs well and is best for anyone with a MTHFR mutation)
*CoQ10 – Co Enzyme Q10 : in the form of ubiquinOL ( the -OL form absorbs best) and I recommend the equivalent of 200mg 3 times a day
*Vit D-if you are vitamin D deficient
*change your diet to lower mercury levels if you have high mercury levels
A healthy well balanced diet and sleeping well is best to optimize fertility and pregnancy.
 
How have infertility treatments and success rates changed in 2020?
Success rates have increased due to the increased use of PGS (preimplantation genetic disorder screening), ZYMOT (which filters the best sperm for IVF), and uterine mock assessments.  Appropriate use of these three technologies have increased per embryo transfer success rates.
Is CoQ10 helpful if you are of advanced maternal age? Are there downsides?
CoQ10 is helpful in increasing ovarian activity.  It cannot increase the number of eggs as women are born with this.  It cannot overcome issues related to age of the egg and lifestyle.  It can increase the risk of bleeding in some patients so I do not recommend women take this when proceeding with an embryo transfer or in pregnancy.
What are the biggest risk factors for pregnancy after age 35 ?
With advancing age, there is an increased risk of miscarriage as there is an increased risk of the embryo having a genetic abnormality. Over the age of 40 with each year, there is an increased risk of preterm delivery, gestational diabetes and preeclampsia.
What are the long term side effects of OHSS?
My practice makes every effort to avoid OHSS. In addition to using low dose medications and monitoring patients very closely and frequently with blood tests and transvaginal ultrasounds and using lupron to trigger ovulation with the lowest dosage of HCG also minimizes the risk of OHSS. When OHSS cannot be avoided, conservative management is key. There are no long term physical effects from OHSS but some of my patients who have experienced this oftentimes describe feeling PTSD like symptoms when proceeding with any treatments.

Ok, so much more you guys, and my favorite questions about how Kelly became a fertility specialist and what she does in her precious free time coming soon. Stay tuned!

xx, Carly
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1 Comment

  1. Shelley
    February 2, 2021 / 3:10 PM

    Love this thank you x

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